This is a more complicated issue than one might think.
Picture, if you will, the movie Die Hard, but in this version the lead character is a woman. You can decide on your own if she's a lesbian, if the employee she's related to is her husband or, like the novel Nothing Lasts Forever, that character is her daughter, it's not important to me here.
What is important is that the film offers a significant amount of physical punishment at the hands of large and cruel villains. It does, in fact, include many of what could be termed "loving" shots of the violence inflicted on him. He is stripped of much of his clothes as well as his dignity, as the movie approaches its climax. To what extent does the change of gender, because of how our society views these things, change the way the average person would view this.
Mind you, other than those factors, it's a solid choice for reversal on most other levels. The most important thing the protagonist brings is sharp wits. The physical elements are much more about endurance and athleticism than of upper body strength.
And, no, I'm not writing a female Die Hard, but it is an interesting illustration of the considerations I'm making in writing.